You can run 1680 for both super and subs when you go over 178gr. Up until you can use 1680 for supers but that is a full case, really full. While h110 can cycle subs, it is not nearly as reliable as 1680 or CFE BLK. So as long as your are over 178, 1680 for both. Under that, h110 super and 168/CFE subs.